hrp0097p1-342 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The relationship between the amount of ghrelin-positive cells in the stomach and the concentration of ghrelin and anti-ghrelin antibodies in the blood in short stature children, with additional analysis of the impact of H. pylori infection.

Kolasa-Kicińska Marzena , Stawerska Renata , Czkwianianc Elżbieta , Stawerski Wojciech , Stawerski Paweł , Foks Maciej , Lewiński Andrzej

Introduction: The growth process in children depends on GH/IGF-1. Ghrelin is stimulator of GH synthesis. Ghrelin also stimulates the orexigenic center peptides responsible for appetite. It is synthesized in the stomach, thus its secretion may be alter by gastrointestinal tract deseases. Recently, high titers of antibodies against some neuropeptides (including anti-ghrelin) have been found in indyviduals with certain microflora components, e.g. Helicobacter pyl...